SUBJECT
Neuronal Cell Differentiation I
lecture
master
2
Semesters 1-4
Autumn/Spring semester
1. The cellular composition of the central nervous tissue;
2. Principles of the neural tissue formation; Ontogenetic formation of the nervous system
3. Generation of neurons and glial cells; germinative zones, neural stem cells; progenitors and precursors; the forle of the Notch-DLS system
4. Activation of proneuronal and neural genes;
5. Cell migration in the developing neural tissue; Molecular bases of cell adhsion and cell motility
6. The formation of layered and core-like neural structures
7. Establishment of cellular polarity in developing neuronal precursors; process outgrowth
8. Process elongation; the axon growth cone, pathfinding of neurites
9. Process-elimination and maintenance: the sorting for persisting neurites
10. Synaptogenesis
11. Activity-dependent synapse and neurite selection; Giant depolarising waves in the developing neural tissue
12. Trophic factors, neural growth factors
13. The formation of glial cells – an overview
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Scott F. Gilbert: Developmental Biology; Palgrave Macmillan, 2003
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Bruce M. Carlson: Human Embryology and Developmental Biology, Elsevier Health Sciences, 2013, ISBN 9781455727940
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Hand-outs of the lectures