SUBJECT
Genetics and Population Genetics
lecture
master
4
Semester 1
Autumn semester
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Historical development of the Gene, allelism and DNA polimorphisms, orthology and paralogy
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Genetics, Genomics,Biotechnology,Bioinformatics : interconnections
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Microbial Genetics and Eucaryotic Genetics Analyses: free passages in complementations, genetic mappings, epistases, mutation, diploidity and partial diploidity
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Genetic analyses and Gene cloning : utilizing phage, plasmid, transposon, bacterium and yeast genetics in gene clonings and in functional analyses of cloned genes. Positional (genetic map based) cloning of genes.
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The genetic map: mapping via recombinational analyses, in situ mappings on chromosomes ,mapping by cell fusions,X-ray mapping,comparative genetic mapping.
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Complementarity and free passages between mapping logics.
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Analyses of gene interactions for dissecting obligate gene cascades, complex structures, signalling pathways. Epistasis , Suppression, Yeast Two Hybrid screen, Gene silencing-phenocopy-epistasis analysis
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Transgenic organisms and their use in genetic analyses, in applied genetics ( industrial, medical, agricultural)
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DNA diagnostics: applications in population and conservational genetics, in historical genetics, in clinical genetics, in plant and animal breeding, in GMO, in microbial industry, etc.
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Microevolution : origin, maintaining, inheritance of phenotypic variability in and in between populations. Varieties for inheritances. Interactions between genotypes-phenotypes, phenotypes-enviroment .
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Macroevolution: origins, extinction of species and taxons, their ecological interactions, and impacts.
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Griffiths A., et al.: Introduction to Genetic Analysis, Freeman and Co., New York, 2010, ISBN 9781464100277
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Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K. and Walter, P.: Molecular Biology of the Cell, Taylor & Francis, 2014, ISBN 9780815344322
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Darnell, J., Lodish, H. and Baltimore D.: Molecular Cell Biology, W. H. Freeman, 2012, ISBN 9781429234139