SUBJECT

Developmental Biology

lecture

master

Faculty of Science

Biology MSc

2

Semester 2

Spring semester

1. History and basic concepts

2. Morphogenesis of the main modell organisms, C. elegans, Drosophila, Xenopus, laboratory rat

3. Organisation of the oocyte, epigenesis and preformation

4. Structure of the sperm cell, molecular mechanism of the fertilisation

5. Mechanisms of segmentation, origin of stem cells

6. Genetics of axis specification in Drosophila and Xenopus

7. The molecular basis of the gastrulation in Drosophila and Xenopus

8. Function of segmentation genes: gap, pair-rule, segment polarity genes and the segment polarity genes

9. Development of the paraxial and intermediate mezoderm

10. The nerulation: classic and molecular approaches

11. Neural crest cells and axonal specifity

12. Organogenesis: the development of the limb and wing on Drosophila and in vertebrates

13. The development of the vertebrate eye, liver, lung and pancreas

14. Early development of the mammals, the function of the placenta

15. Growth and postembrional development

16. Regenaration

17. Evolution and development

• Principles of Development, Wolpert, L. Oxford Univ. Press. 2006

• Developmental Biology Gilbert, S.F., Sinauer Ass., Inc., Sunderland, USA, 2006