SUBJECT

Synthesis of Bioactive Peptides

lecture

Master

Faculty of Science

Chemistry MSc

2

Semester 1

Autumn semester

Amino acids; Behaviour of amino acids under peptide synthesis; Strategies for the synthesis of peptides; Protecting groups (amino-, carboxyl-, side chain protecting groups); Coupling methods; Synthesis of peptides in solution; Removal of protecting groups; Solid phase peptide synthesis; Cleavage technics; Comparison of the synthesis procedures.

Compulsory literature*:

• Stewart JM and Young JD: Solid phase peptide synthesis (Pierce Chemical Company, Rockford, Illinois, 1984) ISBN-13: 978-0935940039

• Atherton E, Sheppard RC: Solid phase peptide synthesis: a practical approach (IRL Press, Oxford, England, 1989)

• Grant GA: Synthetic peptides: A User’s Guide (W.H. Freeman and Company, New York, 1992) ISBN 0-7167-7009-1

• + Publications