SUBJECT

Practicals in Natural Products

practical

Master

Faculty of Science

Chemistry MSc

4

Semester 2/4

Spring semester

Main topics are: synthesis of amino acid derivatives:(N- and C-terminal protection); peptide synthesis in solution and solid phase; synthesis of monosaccharide derivatives.The used separation techniques are chromatography (thin layer-, flash-, high pressure liquid chromatography) nearby crystallization and extraction. The synthetic products will be routinely characterized by simple spectroscopic methods (IR, UV-vis, NMR) and MS.

• M. Bodánszky, Á. Bodánszky: The Practice of Peptide synthesis (Springer Lab Manuals) Springer-Verlag berlin Heidelberg, 1994, ISBN 978-3-540-57505-4

• Methods in Carbohydrate Chemistry (eds. R.L. Whistler, M.L. Wolfrom) 1962, Academic Press, New York, ISBN 10 04771529419,0471529400

• VOGEL’s: Textbook of Practical Organic chemistry (B.S. Furniss, A.J. Hannaford, P.W.G. Smith, A.R. Tatchell) Longman Scientific & Technical, ISBN 0-582-46236-3