SUBJECT
Title
Classics in Total Synthesis
Type of instruction
lecture
Level
Master
Faculty
Part of degree program
Credits
2
Recommended in
Semester 2
Typically offered in
Spring semester
Course description
Selected examples presented among the most remarkable and ingenious total synthesis (e.g. reserpine, prostaglandins, quinine, vitamin B12, taxol, calicheamicin, menthol, epothilones). The mechanism, selectivity and the stereochemistry of the key chemical reactions are discussed thoroughly to make the synthetic strategies more understandable. Catalysis, asymmetric synthesis and organometallic chemistry are especially highlighted.
Readings
Compulsory:
-
Nicolaou K. C., Sorensen E. J. Classics in Total Synthesis , Wiley, 1996 ISBN: 978-3-527-29231-8.
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Nicolaou K. C., Snyder S. A. Classics in Total Synthesis II, Wiley, 2003. ISBN: 978-3-527-30684-8